Malignant Hyperthermia Syndrome
General: Pharmacogenetic disease with uninhibited flow of calcium i 828e42i on into muscle substance; leads to combined metabolic and respiratory acidosis and liberation of heat; cellular death may result; autosomal dominant; more common in children and young adults; unusual disorder of skeletal and cardiac muscle triggered by anesthetic agents.
Ocular: Blepharoptosis; squint; pupils fixed and dilated.
Clinical: Hernias; kyphosis; clubfoot; excessive muscular bulk; muscle cramps; unstable blood pressure; rapid and deep respiration; mottled cyanosis; arrhythmias; muscle rigidity; oliguria; anuria; deep tendon reflexes absent.
Merei GJ, Bell RD. Preoperative management of the surgical patient with neurological disease. Med Clin North Am 1987; 71:511.
Waterman PM. Malignant hyperthermia syndrome. Am J Ophthalmol 1981; 92:461-465.
Waterman PM. Malignant hyperthermia: a case report. Anesth Analg 1980;59:220.
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