Glaucoma, hereditary juvenile

General: Autosomal dominant, present at birth; there has been linkage with chromosome 1q21q23; age at diagnosis is 5 to 30 years; positive family history; male-to-female ratio of 2:1.

Ocular: Dysgenesis of the iris and iridocorneal angle; glaucoma; hypoplasia of iris; dark-colored irides; myopia; smooth iris; prominent iris processes; grayish-pale color of trabecular meshwork.

Clinical: None.

Martin JP, Zorab EC. Familial glaucoma in nine generations of South Hampshire family. Br J Ophthalmol 1974; 58: 536-542.

McKusick VA. Mendelian Inheritance in Man; A Catalog of Human Genes and Genetic Disorders, 12th ed. Baltimore: The Johns Hopkins University Press, 1998.

Online Mendelian Inheritance in Man, OMIM. McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University and National Center for Biotechnology Information, National Library of Medicine, February 12, 2007. World Wide Web URL: https://www.ncbi.nlm.nih.gov/omim/.

Melamed S, Ashkenazi I. Juvenile onset open angle glaucoma. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology, vol. III. Philadelphia: WB Saunders, 1994.