Tritanopia (color blindness; blue color blindness)

General: Autosomal dominant; more common in males; defective blue color vision 848d34i is characteristic; two amino acid substitutions in the gene encoding the blue-sensitive opsin have been detected.

Ocular: Lacking blue and yellow sensory mechanisms while retaining those for red and green; optic atrophy.

Clinical: None.

Boger WP, Petersen RA. Pediatric Ophthalmology. Protan and deutan color blindness. In: Pavan-Langston D, ed. Manual of ocular diagnosis and therapy, 4th ed. Boston: Little, Brown and Company, 1995:285-286.

McKusick VA. Mendelian Inheritance in Man; A Catalog of Human Genes and Genetic Disorders, 12^th ed. Baltimore: The Johns Hopkins University Press, 1998.

Online Mendelian Inheritance in Man, OMIM. McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University and National Center for Biotechnology Information, National Library of Medicine, February 12, 2007. World Wide Web URL: https://www.ncbi.nlm.nih.gov/omim/.

Merin S. The cone dystrophies and color vision disorders. In: Merin S, ed. Inherited eye diseases. New York: Marcel Dekker, 1991:176-l96.

Miyake Y, et al. Differential diagnosis of congenital tritanopia and tritanopia and dominantly inherited juvenile optic atrophy. Arch Ophthalmol 1985; 103:1496-l501.

Weitz CJ, et al. Human tritanopia associated with two amino acid substitutions in the blue sensitive opsin. Am J Hum Genet 1992; 50:498-507.