Reiter syndrome (fiessinger-leroy syndrome; conjunctivo-urethro-synovial syndrome; idiopathic blennorrheal arthritis syndrome; polyarthritis enterica)

General: Etiology unknown; males; onset ages 16 to 42 years; probably a combined infectious/autoimmune pathogenetic mechanism; reactive arthritis probably associated with infection with many different species of microorganisms; HLA-B27 confers disease susceptibility to infection.

Ocular: Sterile mucopurulent conjunctivitis, usually bilateral; photophobia; epiphora; iritis; keratitis; uveitis; paralysis of extraocular muscles; optic neuritis; secondary glaucoma; hypopyon; hyphema.

Clinical: Skin erythema; genital ulcerations; urethritis with discharge; cystitis with dysuria, abacterial pyuria, and hematuria; arthritis with pain, swelling, heat, and effusion; fever; weight loss; fatigue; malaise; fever; diarrhea; oral mucosal lesions; arthralgia.

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Hughes RA, Keat AC. Reiter's syndrome and reactive arthritis: a current view. Semin Arthritis Rheum 1994; 24:190-210.

Kiss S, Letko E, Qamruddin S, et al. Long-term progression, prognosis, and treatment of patients with recurrent ocular manifestations of Reiters syndrome. Ophthalmology 2003; 110: 1764-l769.

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Ostler HB, et al. Reiter's syndrome. Am J Ophthalmol 1971; 71:986.

Vergnani RJ, Smith RS. Reiter's syndrome in a child. Arch Ophthalmol 1974; 91:165.