Leri syndrome (pleonosteosis syndrome; carpal tunnel syndrome)

General: Autosomal dominant type of congenital osseous dystro 717b17h phy; early epiphyseal bone formation of extremities; Morton metatarsalgia syndrome may result; onset in early infancy.

Ocular: Microphthalmia; anophthalmia; oculomotor paralysis; corneal clouding; cataract.

Clinical: Dwarfism (disproportionate); articular deformities; cutaneous deformities; carpal tunnel syndrome (median nerve compression); deformities of thumbs and great toes; laryngeal stenosis.

Geeraets WJ. Ocular Syndromes, 3rd ed. Philadelphia: Lea & Febiger, 1976.

Leri A. Une Dystrophic Osseuse Generalisee et Hereditaire: la Pleonosteose Familiale. Presse Med 1922; 30: 13, and Bull Soc Med Hop (Paris) 1921; 45:1228, 1924; 48:25.

McKusick VA. Mendelian Inheritance in Man; A Catalog of Human Genes and Genetic Disorders, 12th ed. Baltimore: The Johns Hopkins University Press, 1998.

Online Mendelian Inheritance in Man, OMIM. McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University and National Center for Biotechnology Information, National Library of Medicine, February 12, 2007. World Wide Web URL: https://www.ncbi.nlm.nih.gov/omim/.

Shaw DG. Leri's pleonosteosis [Letter]. Br J Radiol l981; 54:819.

Spinner M, Spencer PS. Nerve compression lesions of the upper extremity: a Clinical and experimental review. Clin Orthop 1970; 104:46.