Whipple disease (intestinal lipodystrophy)

General: Multisystem disorder; prominent in males; onset between fourth and se 828h77i venth decades; etiology unknown.

Ocular: Ophthalmoplegia (vertical gaze involved more than horizontal gaze); papilledema; intraocular inflammation; vitreous opacities; bilateral panuveitis; small, round grayish retinal lesions; chemosis; supranuclear ophthalmoplegia; myoclonic ocular jerks; pendular nystagmus.

Clinical: Pneumonia; pleurisy; tonsillitis; sinusitis; cystitis; arthritis; fever; leukocytosis; diarrhea; malabsorption; death; dyspnea; weight loss; lymphadenopathy; polyserositis; gray pigmentation of skin; dementia; facial jerks; rhythmic movement of the mouth, jaw, and extremities.

Durant WJ, et al. Vitrectomy and Whipple's disease. Arch Ophthalmol

Font RL, et al. Ocular involvement in Whipple's disease: light and electron microscopic observations. Arch Ophthalmol 1978; 96:1431-l436.

Gartner J. Whipple's disease of the central nervous system, associated with ophthalmoplegia externa and severe asteroid hyalitis: a clinicopathologic study. Doc Ophthalmol 1980; 49:155-l87.

Knox DL, et al. Cerebral ocular Whipple's disease: a 62-year odyssey from death to diagnosis. Neurology 1995; 45:617-625.

Leland TM, Chambers JK. Ocular findings in Whipple's disease. South Med J 1978; 71:335-338.

Schrenk M, et al. Augenbeteiligung be Morbus Whipple. Klin Monatsbl Augenheilkd 1994; 204:538-541.

Simpson DA, et al. Oculofacial-skeletal myorhythmia in central nervous system Whipple's disease: additional case and review of the literature. Mov Disord 1995; 10:195-200.

Whipple GH. A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp 1907; 18:382-391.