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Wermer Syndrome (Multiple Endocrine Neoplasia 1; MEN1;
Multiple Endocrine Adenomatosis 1;
MEA1; Endocrine Adenoma-Peptic Ulcer Complex; Pluriglandular Adenomatosis n 1
General: Autosomal dominant; high degree of penetrance; both sexes affected; onset after the first decade (see Zollinger-Ellison Syndrome).
Ocular: Visual field defects secondary to pituitary adenoma.
Clinical: Parathyroid adenomas or hyperplasia; pancreatic adenomas; pituitary adenomas; thyroid adenomas; adrenocortical adenomas; subcutaneous lipomas; hypoglycemic crisis; headaches; amenorrhea; diarrhea; weight loss; acromegaly; Cushing syndrome; hyperthyroidism; ulcer; cerebral aneurysm.
Adachi K, et al. Cerebral aneurysm associated with multiple endocrine neoplasia, type l: case report. Neurol Med Chir 1993; 33:309-311.
Magalini SI, Scrascia E. Dictionary of Medical Syndromes, 2nd ed. Philadelphia: JB Lippincott, 1981:860.
Wermer P. Genetic aspects of adenomatosis of endocrine glands. Am J Med 1954; 16:363-371.
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