Sneddon disease

Sneddon Disease 353j95d 353j95d 353j95d 353j95d 353j95d 353j95d

General: Livedo reticularis; neurologic abnormalities; labile hypertension; apparently autosomal dominant inheritance characterized by a rare potentially severe, arterioocclusive disorder; probably an immunologically mediated disorder leading to the migration and proliferation of smooth cells of small arteries, resulting in partial or complete narrowing of the vessel lumen.

Ocular: Central retinal artery occlusion; visual loss; optic atrophy; visual field defect; cherry-red macula.

Clinical: Diffuse headaches; hemihypesthesia; transient aphasic attack; hemianopsia; reticular blue discoloration of skin; hypertension; transient global amnesia; livedo reticularis; progressive neurologic deterioration; multiple ischemic cerebrovascular episodes; renal cell carcinoma.

Carella F, et al. Sneddon's syndrome and renal carcinoma. Case report. Funct Neurol 1992; 7:395-400.

Green KM, et al. Livedo reticularis with ulcers and circulating immune complexes. Cutis 1983; 31:312.

Jones J, et al. Central retinal artery occlusion in Sneddon's disease associated with antiphospholipid antibodies. Am J Ophthalmol 1986; 102:37-40.

Lossos A, et al. Familial Sneddon's syndrome. J Neurol 1995; 242:164-l68.

Sepp N. et al. Sneddon's syndrome-an inflammatory disorder of small arteries followed by smooth muscle proliferation. Immunohistochemical and ultrastructural evidence. Am J Pathol 1995; 19:448-453.

Sneddon IB. Cerebrovascular lesions and livedo reticularis. Br J Dermatol 1965; 77: 180.