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Parkinson Syndrome (Paralysis Agitans; Shaking Palsy)
General: Late stages of epidemic encephalitis; present with arteriosclerosis and with ma 444e47e nganese and carbon monoxide poisoning; widespread destruction of pigmented cells in substantia nigra.
Ocular: Decreased blinking; lid fluttering; blepharospasm; oculogyric crises; ocular hypotony; blepharoplegia; ptosis; nystagmus; paralysis of convergence; paralysis of lateral rectus muscle; absent or sluggish pupillary reactions to light or convergence; mydriasis or anisocoria; optic neuritis; papilledema; abnormal saccades.
Clinical: Slowness of movements; loss of facial expression; 'cogwheel' rigidity of the arms; rhythmical tremors; drooling; shuffling gait; stooping; monotonous voice.
Bronstein AM, Kennard C. Predictive ocular motor control in Parkinson's disease. Brain 1985; 108:925.
Cannon SZ. Basic mechanisms of ocular motor control. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology, vol. IV. Philadelphia: WB Saunders, 1994.
Fraunfelder FT, Roy FH. Current Ocular Therapy, 5th ed. Philadelphia: WB Saunders, 2000.
Guiloff RJ, et al. Reversible supranuclear ophthalmoplegia associated with parkinsonism. J Neurol Neurosurg Psychiatry 1980; 44:552-554.
Parkinson J. An essay on the shaking palsy. London: Sherwood, Nesly and Jones, 1817.
Shibasaki H, et al. Oculo-motor abnormalities in Parkinson's disease. Arch Neurol 1979; 36:360-364.
Shimizu N, et al. Eye-head co-ordination in patients with parkinsonism and cerebellar ataxia. J Neurol Neurosurg Psychiatry 1981; 44:509-515.
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