Nonne-milroy-meige disease (chronic hereditary lymphedema; milroy disease; meige disease; meige-milroy syndrome; nonne-milroy syndrome; chronic hereditary edema; chronic hereditary trophedema; chronic trophedema; elephantiasis congenita hereditaria; familial hereditary edema; hereditary edema; idiopathic hereditary lymphedema; pseudoedematous hypodermal hypertrophy; pseudoelephantiasis neuroarthritica; oromandibular dystonia; blepharospasm-oromandibular dystonia; congenital trophedema; tropholymphedema; trophoneurosis; elephantiasis arabum congenita) 8

General: Autosomal dominant; prevalent in females; two types: praecox at birth to 35 years and tarda after age 35 years.

Ocular: Lid and conjunctival edema; blepharoptosis; distichiasis; strabismus; buphthalmos; ectropion.

Clinical: Lymphedema; mandibulofacial dysostosis; unilateral or bilateral edema of ankle ascending to the knee and eventually above; rough, pigmented skin over swollen parts.

Geeraets WJ. Ocular Syndromes, 3rd ed. Philadelphia: Lea & Febiger, 1976.

McKusick VA. Mendelian Inheritance in Man; A Catalog of Human Genes and Genetic Disorders, 12^th ed. Baltimore: The Johns Hopkins University Press, 1998.

Online Mendelian Inheritance in Man, OMIM. McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University and National Center for Biotechnology Information, National Library of Medicine, February 12, 2007. World Wide Web URL: https://www.ncbi.nlm.nih.gov/omim/.

Meige H. Le Trophoedeme Chronique Hereditaire. Nouv Salpetrieie 1899; 12:453-480.

Milory WF. An undescribed variety of hereditary edema. NY Med J 1892; 56:505-508.

Nonne M. Vier Falle von Elephantiasis Congenita Hereditaria. Arch Pathol Anat 1891; 125:184-l96.

Tabbara KF, Baghdassarian SA. Chronic hereditary lymphedema of the legs with congenital conjunctival lymphedema. Am J Ophthalmol 1972; 73:531-532.