Legg-Perthes Disease (Legg-Calve-Perthes Disease;
Legg-Calve-Waldenstrom Syndrome; Coxa a;
Legg Disease; Legg-Calve Disease) 111f57b 111f57b 111f57b 111f57b 111f57b
General: Etiology not established; occurs in children between ages 3 and 12 years; more common in boys; unilateral involvement more common than bilateral; retardation of bone age; occasionally familial; rare in blacks; possible role for protein C and S deficiency, thrombophilia, venous hypertension, and hypofibrinolysis in the pathophysiologic mechanism of this disease.
Ocular: Iris processes (pectinate ligaments in the anterior chamber angle).
Clinical: Osteochondrosis of the capitular epiphysis of the femur; limpness associated with muscular spasm.
Glueck CJ, et al. Protein C deficiency, thrombophilia, and hypofibrinolysis: pathophysiologic causes of Legg-Perthes disease. Pediatr Res 1994; 35[4 Part 1]:383-389.
Legg AT. The cause of atrophy in joint disease. Am J Orthop Surg 1908-l909; 6:84-90.
Lichter PR. Iris processes in 340 eyes. Am J Ophthalmol 1969; 68:872-878.
Liu SI, Ho TC. The role of venous hypertension in the pathogenesis of Legg-Perthes disease. A Clinical and experimental study. J Bone Joint Surg Am 1991; 73:194-200.
Perthes G. Uber Arthritis Deformans Juvenilis. Dtsch Z Chir 1910; 107:111-l59.
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