Graft Versus Host Disease
General: Major complication of bone marrow transtation 919b15j ; donor T lymphocytes attack recipient's cells; targets are skin, liver, intestine, oral mucosa, conjunctiva, lacrimal gland, vaginal mucosa, and esophageal mucosa.
Ocular: Keratoconjunctivitis; photophobia; hemorrhagic conjunctivitis; proptosis; intraretinal hemorrhages; nerve palsy; herpes simplex/herpes zoster manifestations; uveitis; corneal epithelial denudement; conjunctival scarring; dry eye syndrome; corneal melt; dacryoadenitis; keratoconjunctivitis sicca; cataract; retinitis.
Clinical: Leukemia; aplastic anemia; exanthematous dermatitis; hepatitis; enteritis; scleroderma-like involvement of skin; chronic liver dysfunction; recurrent bacterial infections.
Foster CS. Immunologic disorders of the conjunctiva, cornea and sclera. In: Albert DM, Jakobiec FA, eds. Principles and Practice of Ophthalmology, vol. I. Philadelphia: WB Saunders, 1994.
Jack MK, et al. Ocular manifestations of graft versus host disease. Arch Ophthalmol 1983; 101:1080-l084.
Lawley TJ, et al. Sjogren-like syndrome and chronic graft versus host disease. Ann Intern Med 1977; 87:707-709.
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