Glucagonoma Syndrome
General: Alpha-cell islet tumor of panc 121e44b reas with retrobulbar neuritis first sign and necrolytic migratory erythema early signs.
Ocular: Central scotoma; retrobulbar neuritis.
Clinical: Necrolytic migratory erythema; diabetes; hypoaminoacidemia and hyperglucagonemia secondary to alpha-cell islet tumor of panc 121e44b reas; anemia; glossitis; weight loss; angular stomatitis; onycholysis; diarrhea; monochromic monocytic anemia; recurrent venous thrombosis (associated with alpha-cell tumor).
Holmes A, et al. Reversal of a neurologic paraneoplastic syndrome with octreotide (Sandostatin) in a patient with glucagonoma. Am J Med 1991; 91:434-436.
Lambrecht ER, et al. Retrobulbar neuritis as first sign of glucagonoma syndrome. Int Ophthalmol 1987; 11:14-l6.
Vandersteen PR, et al. Glucagonoma syndrome: a clinicopathologic immunocytochemical and ultrastructural study. J Am Acad Dermatol 1985; 12:1032-l039.
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