Fuchs-Lyell Syndrome (Debr-Lamy-Lyell Syndrome; Toxic Epidermal Necrolysis) 4
General: Allergic reaction with severe manifestations; si 242i88c milar to Fuchs-Salzmann- Terrien syndrome (see Fuchs-Salzmann-Terrien Syndrome); may result as a reaction to Staphylococcus aureus toxin in children or associated with certain medications, including penicillin, sulfa, nonsteroidal antiinflammatory agents, and allopurinol.
Ocular: Obstruction of nasolacrimal duct; cicatricial changes in conjunctiva and cornea; conjunctivitis; symblepharon; corneal ulceration and possible perforation.
Clinical: Inflammation of mucous membrane with ulcerations; general epidermolysis; cicatricial changes, especially of orifices.
Geeraets WJ. Ocular Syndromes, 3rd ed. Philadelphia: Lea & Febiger, 1976.
Lyell A. Toxic epidermal necrolysis: eruption resembling scalding of skin. Dr J Dermatol 1956; 68:355.
Reich H, Junemann G. Das Debre-Lamy-Lyell-Syndrom. Klin Monatsbl Augenheilkd 1970; 157:358.
Westly ED, Wechsler HL. Toxic epidermal necrolysis. Arch Dermatol 1984; 120:721.
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