Down syndrome (mongolism; trisomy g; trisomy 21 syndrome; mongoloid idiocy) 383

General: Trisomy of chromosome 21.

Ocular: Hypertelorism; epicanthus; blepharitis; ectropion; nystagmus; esotropia; high myopia (30%); hyperopia; color blindness; yellow spots on the iris; hypoplasia of the iris; blepharoconjunctivitis; lens opacities (50%); keratoconus (may be acute); corneal hydrops; corneal ectasia; corneal edema; leukoma; lateral displacement of canaliculi and puncta; megaloblepharon; euryblepharon; decreased accommodation; Leber congenital amaurosis.

Clinical: Mental retardation; skeletal abnormalities; overextension of joints; deformed and low-set ears; short fifth finger; transverse palmar crease; fissured tongue; heart anomalies.

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