Distichiasis (distichiasis with congenital anomalies of the heart and peripheral vasculature)    376

General: Autosomal dominant.

Ocular: Double rows of eyelashes; congenital ectropion; absence of meibomian glands; replacement of dense collagenous tissue of the tarsal plates by loose areolar tissue.

Clinical: Congenital heart defects; ventricular septal defects; stress-induced asystole; visible varicosities; chronic venous disease of the legs; sinus bradycardia.

Goldstein S, et al. Distichiasis, congenital heart defects, and mixed peripheral vascular anomalies. Am J Med Genet 1985; 20:283-294.

McKusick VA. Mendelian Inheritance in Man; A Catalog of Human Genes and Genetic Disorders, 12th ed. Baltimore: The Johns Hopkins University Press, 1998.

Online Mendelian Inheritance in Man, OMIM. McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University and National Center for Biotechnology Information, National Library of Medicine, February 12, 2007. World Wide Web URL: https://www.ncbi.nlm.nih.gov/omim/.